Biotech Manufacturing Companies in South Dakota

South Dakota has approximately 900 manufacturing establishments and 46,000 manufacturing employees. South Dakota's manufacturing sector is led by food processing operations in Sioux Falls, with additional strength in metal fabrication and agricultural equipment.

South Dakota contributes to the national biotech manufacturing landscape. Biotech manufacturing encompasses the production of biologic drugs including monoclonal antibodies, cell and gene therapies, vaccines, and recombinant proteins. Unlike traditional pharmaceutical manufacturing, biotech production relies on living cell systems and requires specialized bioprocessing equipment, single-use systems, and advanced purification technologies.

Monoclonal Antibody Producers: Companies operating large-scale mammalian cell culture facilities for antibody drug production.

Cell Therapy Manufacturers: Facilities producing autologous and allogeneic cell therapies including CAR-T and stem cell products.

Gene Therapy Producers: Companies manufacturing viral vectors (AAV, lentivirus) for gene therapy applications.

Vaccine Manufacturers: Facilities producing vaccines using traditional and mRNA platforms, including fill-finish operations.

Contract Biologics Manufacturers: CDMOs specializing in biologic drug manufacturing, from cell line development through commercial production.

Major industrial centers in South Dakota include Sioux Falls, Rapid City, and Aberdeen. These cities have concentrations of manufacturers across sectors including food processing manufacturing, metal fabrication, and agricultural equipment manufacturing.