Biotech Manufacturing Companies in California

California has approximately 35,000 manufacturing establishments and 1,300,000 manufacturing employees. California is the largest manufacturing state by output, leading in aerospace, semiconductors, medical devices, and food processing across its diverse regional economies.

California is one of the leading states for biotech manufacturing. Biotech manufacturing encompasses the production of biologic drugs including monoclonal antibodies, cell and gene therapies, vaccines, and recombinant proteins. Unlike traditional pharmaceutical manufacturing, biotech production relies on living cell systems and requires specialized bioprocessing equipment, single-use systems, and advanced purification technologies.

Monoclonal Antibody Producers: Companies operating large-scale mammalian cell culture facilities for antibody drug production.

Cell Therapy Manufacturers: Facilities producing autologous and allogeneic cell therapies including CAR-T and stem cell products.

Gene Therapy Producers: Companies manufacturing viral vectors (AAV, lentivirus) for gene therapy applications.

Vaccine Manufacturers: Facilities producing vaccines using traditional and mRNA platforms, including fill-finish operations.

Contract Biologics Manufacturers: CDMOs specializing in biologic drug manufacturing, from cell line development through commercial production.

Major industrial centers in California include Los Angeles, San Diego, San Jose, San Francisco, Fresno, Irvine, and Long Beach. These cities have concentrations of manufacturers across sectors including semiconductor manufacturing, aerospace manufacturing, and medical device manufacturing.