Biotech Manufacturing Companies in Massachusetts

Massachusetts has approximately 5,800 manufacturing establishments and 245,000 manufacturing employees. Massachusetts is a leader in medical devices, biotech manufacturing, and defense electronics, with Route 128 and the I-495 corridor forming a high-tech manufacturing belt.

Massachusetts is one of the leading states for biotech manufacturing. Biotech manufacturing encompasses the production of biologic drugs including monoclonal antibodies, cell and gene therapies, vaccines, and recombinant proteins. Unlike traditional pharmaceutical manufacturing, biotech production relies on living cell systems and requires specialized bioprocessing equipment, single-use systems, and advanced purification technologies.

Monoclonal Antibody Producers: Companies operating large-scale mammalian cell culture facilities for antibody drug production.

Cell Therapy Manufacturers: Facilities producing autologous and allogeneic cell therapies including CAR-T and stem cell products.

Gene Therapy Producers: Companies manufacturing viral vectors (AAV, lentivirus) for gene therapy applications.

Vaccine Manufacturers: Facilities producing vaccines using traditional and mRNA platforms, including fill-finish operations.

Contract Biologics Manufacturers: CDMOs specializing in biologic drug manufacturing, from cell line development through commercial production.

Major industrial centers in Massachusetts include Boston, Worcester, Springfield, Lowell, and Cambridge. These cities have concentrations of manufacturers across sectors including medical device manufacturing, semiconductor manufacturing, and defense manufacturing.