Biotech Manufacturing Companies in Tennessee

Tennessee has approximately 6,500 manufacturing establishments and 370,000 manufacturing employees. Tennessee is a leading automotive manufacturing state with Nissan, GM, and Volkswagen assembly plants, plus a growing medical device corridor and extensive auto supplier network.

Tennessee contributes to the national biotech manufacturing landscape. Biotech manufacturing encompasses the production of biologic drugs including monoclonal antibodies, cell and gene therapies, vaccines, and recombinant proteins. Unlike traditional pharmaceutical manufacturing, biotech production relies on living cell systems and requires specialized bioprocessing equipment, single-use systems, and advanced purification technologies.

Monoclonal Antibody Producers: Companies operating large-scale mammalian cell culture facilities for antibody drug production.

Cell Therapy Manufacturers: Facilities producing autologous and allogeneic cell therapies including CAR-T and stem cell products.

Gene Therapy Producers: Companies manufacturing viral vectors (AAV, lentivirus) for gene therapy applications.

Vaccine Manufacturers: Facilities producing vaccines using traditional and mRNA platforms, including fill-finish operations.

Contract Biologics Manufacturers: CDMOs specializing in biologic drug manufacturing, from cell line development through commercial production.

Major industrial centers in Tennessee include Nashville, Memphis, Chattanooga, Knoxville, Spring Hill, and Smyrna. These cities have concentrations of manufacturers across sectors including automotive oem manufacturing, automotive tier 1 suppliers, and food processing manufacturing.