Biotech Manufacturing Companies in Minnesota

Minnesota has approximately 6,800 manufacturing establishments and 320,000 manufacturing employees. Minnesota is the medical device capital of the world, home to Medtronic, Boston Scientific, and 3M, with additional strength in food processing and precision manufacturing.

Minnesota contributes to the national biotech manufacturing landscape. Biotech manufacturing encompasses the production of biologic drugs including monoclonal antibodies, cell and gene therapies, vaccines, and recombinant proteins. Unlike traditional pharmaceutical manufacturing, biotech production relies on living cell systems and requires specialized bioprocessing equipment, single-use systems, and advanced purification technologies.

Monoclonal Antibody Producers: Companies operating large-scale mammalian cell culture facilities for antibody drug production.

Cell Therapy Manufacturers: Facilities producing autologous and allogeneic cell therapies including CAR-T and stem cell products.

Gene Therapy Producers: Companies manufacturing viral vectors (AAV, lentivirus) for gene therapy applications.

Vaccine Manufacturers: Facilities producing vaccines using traditional and mRNA platforms, including fill-finish operations.

Contract Biologics Manufacturers: CDMOs specializing in biologic drug manufacturing, from cell line development through commercial production.

Major industrial centers in Minnesota include Minneapolis, St. Paul, Rochester, Duluth, and Bloomington. These cities have concentrations of manufacturers across sectors including medical device manufacturing, food processing manufacturing, and metal fabrication.